Emulate Brain-Chip to Study the Effects of Microgravity on Human Brain Physiology at the International Space Station

BOSTON, December 21, 2021 (Emulate PR) – Emulate, Inc., a leading provider of next-generation in vitro models, today announced that the Brain-Chip was sent to the International Space Station U.S. National Laboratory (ISS National Lab) to study the effects of microgravity on human brain physiology as part of the Tissue-Chips in Space initiative sponsored by the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) and the International Space Station National Lab (ISS-NL). The ISS provides an environment where researchers can study human health in microgravity, allowing them to isolate the effects of gravity from other factors that can impact brain cell function. 

The Emulate Brain-Chip is the most comprehensive in vitro model of the human neurovascular unit, including the blood-brain barrier (BBB), for preclinical research. It contains five cell types in a dynamic and tunable microenvironment, resulting in in vivo-like gene expression and phenotypic response. Each chip is about the size of a USB thumb drive and contains two fluidic channels separated by a porous membrane. The vascular channel is lined with brain microvascular endothelial cells, while the brain channel contains cortical neurons, astrocytes, pericytes, and microglia. This allows researchers to study BBB function, the ability of drugs to cross the BBB, and the complex cell-cell interactions involved in brain physiology, disease, and drug response.

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SpaceX CRS-24 Launching Multiple Life Science Investigations to International Space Station

KENNEDY SPACE CENTER, Fla., December 15, 2021 (CASIS PR) – The microgravity environment on the International Space Station (ISS) has a profound impact on cells and tissues, allowing researchers to conduct life sciences research in ways not possible on the ground. SpaceX’s 24th Commercial Resupply Services (CRS) mission to the orbiting laboratory will deliver a variety of life science payloads sponsored by the ISS National Lab. From stem cell research on neurodegenerative diseases to a tissue chip experiment studying the blood-brain barrier and an investigation testing the use of bacteria to protect DNA from the stresses of spaceflight—the research launching on this mission is helping to improve the quality of life for people on Earth.

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SpaceX’s 22nd Commercial Resupply Mission to Space Station Launches Water Bears, Squids, Solar Panels

These immature bobtail squid (Euprymna scolopes) are part of UMAMI, an investigation that examines whether space alters the symbiotic relationship between the squid and the bacterium Vibrio fischeri. (Credits: Jamie S. Foster, University of Florida)

HOUSTON (NASA PR) — The 22nd SpaceX cargo resupply mission carrying scientific research and technology demonstrations launches to the International Space Station from NASA’s Kennedy Space Center in Florida no earlier than June 3. Experiments aboard include studying how water bears tolerate space, whether microgravity affects symbiotic relationships, analyzing the formation of kidney stones, and more.

Highlights of the payloads on this resupply mission include:

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SpaceX Crew-2 Astronauts Will Perform a Wide Variety of Research During Six-Month Mission

KENNEDY SPACE CENTER, Fla., April 26, 2021 (CASIS PR) – Early Friday morning, NASA’s SpaceX Crew-2 mission launched four astronauts to the International Space Station (ISS) from Kennedy Space Center’s Launch Pad 39A. After a successful launch of the Falcon 9 rocket into low Earth orbit, the SpaceX Crew Dragon trailed the orbiting laboratory until Saturday morning, when the spacecraft successfully docked. On this mission, the second under NASA’s Commercial Crew Program, NASA astronauts Shane Kimbrough and Megan McArthur, Japanese Aerospace Exploration Agency astronaut Akihiko Hoshide, and European Space Agency astronaut Thomas Pesquet joined the other members of the ISS Expedition 65 crew.

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SpaceX CRS-21 Safely Splashes Down Off the Coast of Florida, Returning Science From the Space Station Back to Earth

KENNEDY SPACE CENTER, Fla., January 14, 2021 (CASIS PR)  – SpaceX’s Dragon spacecraft splashed down safely off the coast of Florida last night, concluding a month-plus stay at the International Space Station (ISS) to bring back thousands of pounds of scientific research and cargo.

With this successful splashdown, SpaceX completed its 21st Commercial Resupply Services (CRS) mission to the orbiting laboratory for NASA. This also marks the first mission of the upgraded Dragon cargo spacecraft with double the powered locker capacity of previous capsules, allowing for even more research to travel back to Earth for analysis.

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Crew-1 Heads to Space Station to Conduct Microgravity Science

NASA astronauts Shannon Walker, left, Victor Glover, second from left, Mike Hopkins, second from right, and Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, right, are introduced by Kennedy Space Center Director Bob Cabana after arriving at the Launch and Landing Facility at NASA’s Kennedy Space Center ahead of SpaceX’s Crew-1 mission, Sunday, Nov. 8, 2020, in Florida. (Credit: NASA/Joel Kowsky)

HOUSTON (NASA PR) — Expedition 1 and Crew-1. These historic International Space Station missions lifting off 20 years apart share the same goals: advancing humanity by using the space station to learn how to explore farther than ever before, while also conducting research and technology demonstrations benefiting life back on Earth.

Crew-1, made up of NASA astronauts Shannon Walker, Victor Glover, and Mike Hopkins, and Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, continues the legacy of two decades of living and working in low-Earth orbit by becoming space scientists for the next six months.

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SpaceX Dragon Returns ISS National Lab-sponsored Payloads to Earth

KENNEDY SPACE CENTER, Fla., April 7, 2020 (ISS National Lab PR) – SpaceX’s Dragon spacecraft successfully splashed down today off the coast of California, bringing back dozens of research investigations sponsored by the International Space Station (ISS) U.S. National Laboratory.

The successful splashdown and science return marks the completion of SpaceX’s 20th commercial resupply services (CRS) mission to the space station (contracted by NASA) to send critical research and supplies to the orbiting laboratory. The Dragon spacecraft spent approximately 30 days berthed to the space station before returning to Earth.

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